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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MARK1
All Species:
14.55
Human Site:
Y494
Identified Species:
26.67
UniProt:
Q9P0L2
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9P0L2
NP_061120.3
795
89003
Y494
T
I
P
S
N
N
V
Y
S
G
G
S
M
A
R
Chimpanzee
Pan troglodytes
XP_001172839
796
89049
S495
I
P
S
N
N
V
Y
S
G
G
S
M
A
R
R
Rhesus Macaque
Macaca mulatta
XP_001115611
778
86745
T479
N
S
V
L
S
T
S
T
N
R
S
R
N
S
P
Dog
Lupus familis
XP_536123
782
87409
Y481
T
I
P
S
S
N
V
Y
P
G
G
S
M
A
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8VHJ5
795
88528
Y494
A
S
P
S
N
N
V
Y
S
G
G
S
M
A
R
Rat
Rattus norvegicus
O08678
793
88216
Y494
A
G
P
S
N
N
V
Y
S
G
G
S
M
T
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511751
793
88836
F492
T
I
P
S
N
N
V
F
P
G
G
G
M
T
R
Chicken
Gallus gallus
Q9IA88
798
88848
S468
D
H
P
I
R
I
P
S
N
T
S
R
R
H
T
Frog
Xenopus laevis
NP_001085126
792
88624
F494
A
G
T
S
N
S
L
F
P
G
S
G
M
T
R
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
L622
I
Q
A
Y
K
T
Q
L
E
N
N
S
L
I
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
G891
N
M
G
A
S
S
G
G
A
A
A
A
A
S
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
N222
T
L
P
F
D
D
E
N
I
P
N
L
F
K
K
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
E343
G
S
S
P
D
N
D
E
I
D
D
N
L
V
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
68.9
95.9
N.A.
94.9
94.3
N.A.
92.8
30.4
88.6
27.8
N.A.
N.A.
N.A.
40.7
N.A.
Protein Similarity:
100
99.3
80.2
96.8
N.A.
97.3
96.9
N.A.
95.9
51.3
94.2
44
N.A.
N.A.
N.A.
51
N.A.
P-Site Identity:
100
20
0
86.6
N.A.
86.6
80
N.A.
73.3
6.6
33.3
13.3
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
100
26.6
20
93.3
N.A.
86.6
80
N.A.
80
13.3
53.3
20
N.A.
N.A.
N.A.
46.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.9
28
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.4
46.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
24
0
8
8
0
0
0
0
8
8
8
8
16
24
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
16
8
8
0
0
8
8
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
8
8
8
0
0
0
0
0
0
% E
% Phe:
0
0
0
8
0
0
0
16
0
0
0
0
8
0
0
% F
% Gly:
8
16
8
0
0
0
8
8
8
54
39
16
0
0
0
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
16
24
0
8
0
8
0
0
16
0
0
0
0
8
0
% I
% Lys:
0
0
0
0
8
0
0
0
0
0
0
0
0
8
8
% K
% Leu:
0
8
0
8
0
0
8
8
0
0
0
8
16
0
0
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
8
47
0
0
% M
% Asn:
16
0
0
8
47
47
0
8
16
8
16
8
8
0
8
% N
% Pro:
0
8
54
8
0
0
8
0
24
8
0
0
0
0
8
% P
% Gln:
0
8
0
0
0
0
8
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
8
0
0
0
0
8
0
16
8
8
62
% R
% Ser:
0
24
16
47
24
16
8
16
24
0
31
39
0
16
0
% S
% Thr:
31
0
8
0
0
16
0
8
0
8
0
0
0
24
8
% T
% Val:
0
0
8
0
0
8
39
0
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
8
31
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _